YHK research data

1

Effect and Application of Yojyo Henshiko

S. Sha 1), N. Yanaihara 2)

Conferences

16th General Meeting of Medical and Pharmaceutical Society for Wakan-Yaku
28th~29th August 1999 – Makuhari, Japan

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2

Clinical Trials

Clinical Application and Efficacy of a New Chinese Medical Herb Prescription: “Yojyo Henshiko”

S. Sha 1), N. Yanaihara 2)

Conferences

2nd Annual Meeting of the Japanese Society for Alternative Medicine & Treatment
28th~29th August 1999 – Makuhari, Japan

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3

Effect of “Yojyo Henshiko, a new Chinese Herb Prescription”, on Serum ALT and AST Levels in Patients with Hepatic Diseases

S. Sha 1), M.Harada 2), N. Yanaihara 3)

Conferences

3rd International Conference on Therapies for Viral Hepatitis
12th~16th December 1999 – Maui, Hawai, U.S.A.

IASL-APASL JOINT MEETING 2000
2nd~7th June 2000 – Fukuoka, Japan

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4

Beneficial Effect of a Controlled Chinese Herbal Remedy, K-17.22, in CCL4-Induced Liver Toxicity; an in Vivo and in Vitro Study

F.Marotta 1), A.Rouge 2), H.Anzulovic 2), M.Harada 3), G.M.Ideo 1), K.Kajikawa 4), N.Yanaihara 5), G.Princess 2), G.Ideo 1)

Conferences

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
7th~9th June 2001 – Shimonoseki, Japan

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

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5

Ischemia-Reperfusion Liver Injury: Effect of a Nutritional Approach with K-17.22 on Eudogenous Hepatic Antioxidant System

F.Marotta 1), G.M.Ideo 1), MG Seal 2), CC Wu 3), P Safran 2), M.Harada 4), N. Yanaihara 4), G.Ideo 1)

Conferences

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
6th~9th June 2001 – Shimonoseki, Japan

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6

A Nutritional Approach with Herbal Remedy K-17.22 Delays the Onset of Spontaneous Chronic Pancreatitis

F.Marotta 1), M.Harada 2), MG Seal 2), J.Bertuccelli 3), A.Rouge 3), H.Anzulovic 3), N.Yanaihara 4), G.Ideo 1)

Conferences

25th National Congress of the Italian Association of Pancreatology Study
20th~22nd June 2001 – Como, Italy

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7

Effect of a Nutritional Approach with K-17.22 on Endogenous Hepatic Antioxidant System

F.Marotta, M. Harada, N. Yanaihara, G.M. Ideo, MG Seal, CC Wu, P Safran, G.Ideo

Conferences

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

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8

The Effect of the Yojyo Hen Shi Ko for the liver diseases -Specially for the Hepatitis Type C

M.Harada, N.Yanaihara, F.Marotta, I.Yoshijima, H.Shimizu, K.Hosokawa, Y.Tsuji, Y.Harada, S.Sha

Conferences

The 43th The Journal of All Japan Hospital Association
20th October 2001 – Saitama, Japan

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9

The Effect of the Tablets

S. Sha 1), M. Harada 2), N. Yanaihara 3)

Conferences

The 4th Annual Meeting of the Japanese Society for Alternative Medicine and Treatment
10th~11th November 2001 – Osaka, Japan

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10

Clinical Trials

Effect of “Yojyo Henshiko (YHK)”, in Patients with Hepatic Diseases

S. Sha 1), M. Harada 2), N. Yanaihara 3)

Conferences

HEP DART 2001
16th~20th December 2001 – Maui, Hawai, U.S.A.

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11

Effect of K-17.22, a Novel Phytoterapeutic Agent, on DNA Synthesis and Liver Enzyme Release in Experimental Liver Damage

F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), A.Helmy 4), P.Safran 2), M.Harada 5)

Conferences

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

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12

Is There Any Liver Anti-Fibrotic Effect of K-17.22? An Experimental Study with Immunohistochemical Analysis in A Rat Model

F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), E. Oliva 4), P.Safran 2), M.Harada 5)

Conferences

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

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13

Clinical Trials

Award-winning

YHK, A Novel Herbal Remedy with Effective Antifibrotic Action, in Chronic Liver Disease: A Pilot Clinical Study Aiming to a Successful Integrative Medicine Development

M.Harada 1), F.Marotta 2), S.Sha 3), E.Minelli 4)

Conferences

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

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14

Effect of a Novel Phytoterapeutic on DNA Synthesis and Enzyme Release In Experimental Liver Damage

F.Marotta 1), YR-Shield 2), E.Minelli 3), A Helmy 4), P.Safran 2)

Conferences

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

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15

For “Shining of Life Force”-Basics & Potential Contribution of Yojyo Foods

S. Sha

Conferences

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

16

An In Vitro Study on the Beneficial Effect of YHK, A Natural Herbal Compound, on Metal-Induced Oxidative Damage of Hepatocytes and Mithocondrial Fraction

F.Marotta 1), P.LeCroix 2), M.Harada 3), K.Masulair 4), C.Turnes 2), P.Safran 3), E.Fesce 1)

Conferences

7th International ISSX Meeting
29th August~2nd September 2004 – Vancouver, Canada

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17

Herbal Products for Liver Disease: A Therapeutic Challenge for the New Millenium

F.Marotta

Conferences

Hiroshima University M.D. Lecture Presentation
4th October 2004 – Hiroshima, Japan

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18

Award-winning

Exploring Strategies to Treat NASH: Beneficial Effect of YHK on Metal-Induced Oxidative Damage of Hepatocytes and Lysosomal Fraction

F.Marotta, P.LeCroix, M.Harada, K.Masulair, C.Turnes, L.Mondazzi, P.Safran, E.Fesce

Conferences

Third JSH Single Topic Conference
7th~8th October 2004 – Kochi, Japan

4th World Congress on Trauma, Sjock, Inflammation and Sepsis – Pathophysiology, Immune Consequences and Therapy
4th November 2004 – Munich, Germany

2nd Natural Health Product Conference
11th~13th February 2005 – Vancouver, Canada

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19

Integrative Medicine in the III Millenium: Herbal Products for Liver Disease

F. Marotta, E. Minelli, U. Solimene, SH Sha.

Conferences

Saudi Gastroenterology Association
10th November~2nd December 2004 – Saudi Arabia

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20

Herbal Products for Liver Disease

Conferences

Asian Pacific Association for the Study of the Liver(APASL) Conference 2004
11th December 2004~15th January 2005 – New Delhi, India

21

International Medical Journal Publishes Research

Liver Exposure to Xenobiotics: The Aging Factor and Potentials for Functional Foods

F. MAROTTA, P. LECROIX, M. HARADA, K. MASULAIR, P. SAFRAN, A. LORENZETTI, SK ONO-NITA, and P. MARANDOLA

Publication

REJUVENATION RESEARCH Volume 9, Number 2, 2006

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22

Clinical Trials

International Medical Journal Publishes Research

Yo Jyo Hen Shi Ko (YHK) Improves Transaminases in Nonalcoholic Steatohepatitis(NASH): A Randomized Pilot Study

Nilesh Chande, Maggie Laidlaw, Paul Adams, Paul Marotta

Conferences

1st Annual Canadian Association for the Study of the Liver Winter Meeting: Updates in Hepatology
19th~22nd March 2005 – Canada

Publication

Digestive Diseases and Sciences 2006

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23

Carcinogen-Metabolizing Enzyme Activity in the Liver: Beneficial Effect of the Phytotherapeutic Compound YHK

F. Marotta 1), P. LeCroix 2), M. Harada 3), K. Masulair 4), P. Safran 3), E. Fesce 1)

Conferences

8th World Congress on Gastrointestinal Cancer
28th June~1st July 2006 – Barcelona, Spain

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24

International Medical Journal Publishes Research

Nonalcoholic Steatohepatitis (NASH) in OB/OB Mice Treated with Yo Jyo Hen Shi Ko (YHK): Effects on Peroxisome Proliferator-Activated Receptors (PPARs) and Microsomal Triglyceride Transfer Protein (MTP)

J. T. Stefano, C. P. M. S. de Oliveira, M. L. Correˆa-Giannella, V. M. R. de Lima, S. V. de Sa, E. P. de Oliveira, E. S. de Mello, D. Giannella-Neto, V. A. F. Alves, F. J. Carrilho

Publication

Digestive Diseases and Sciences Vol.52, 2007

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25

International Medical Journal Publishes Research

YHK(YojyoHenshiKo), a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet

Lima V.M.1, Oliveira C.P 1), Sawada L.Y 1), Barbeiro H.V 2), Mello E.S 3), Soriano F.G 2), Alves V.A.F 3), Caldwell S.H 4), Carrilho F.J 1)

Publication

“Liver International” Volume 27, Issue2

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26

International Medical Journal Publishes Research

In vitro study on the mechanisms of action of a novel phytotherapeutic compound against human hepatoma cells

F Marotta;1,3 M Harada;2 KL Goh;3 A Lorenzetti;4 P Marandola;4 E Minelli 1

Publication

Annals of Hepatology
1st April 2007

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27

International Medical Journal Publishes Research

Phytotherapeutic compound YHK exerts an inhibitory effect on early stage of experimentally-induced neoplastic liver lesions

Marotta F;1,4 Harada M;2 Goh KL;3 Lorenzetti A;1 Gelosa F;1 Minelli E4

Conferences

International Symposium on: Functional Foods in Europe – International Developments in Science and Health Claims
9th~11th May 2007 – St Julian’s, Malta

American Institute for Cancer Research (AICR) Annual Conference on Food, Nutrition, Physical Activity and Cancer
6th~7th November 2008 – Washington DC, U.S.A.

Publication

Annals of Hepatology 2006

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28

Inhibitory Action of a Novel Phytotherapeutic Compound Against Human Hepatoma Cells

1Minelli E., 2Harada M., 1, 3Marotta F., 3Goh KL

Conferences

American Institute for Cancer Research (AICR) Annual Conference on Food, Nutrition, Physical Activity and Cancer
6th~7th November 2008 – Washington DC, U.S.A.

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29

International Medical Journal Publishes Research

Anti-inflammatory And Anti-mutagenic Effect Of Yhk Phytocompound In Hepatocytes: In View Of An Age-management Liver Protecting Approach

Conferences

Strategies for Engineered Negligible Senescence (SENS), Sixth Conference
3rd~7th September 2013

Publication

Rejuvenation Research 2013

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30

International Medical Journal Publishes Research

Yo Jyo Hen Shi Ko (YHK) Modulates the Expression of Proteins Involved in de novo Lipogenesis and Lipid Exportation in Experimental Nonalcoholic Steatohepatitis (NASH)

I. Pereira, C. de Oliveira, J. Stefano, V. Debas, N. Halla, J. Alves, F. Laurindo, F. Carrilho

Publication

Journal of Pharmacy and Nutrition Science 2013

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31

The use of nutraceuticals in chronic liver disease: Myths, Facts and Dangers

Marotta F

Conferences

AMMG 14th Clinical Applications for Age Management Medicine
2nd~5th May 2013

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32

A study of Chinese Medical herb prescription prevents Chronic and other liver disease

1 S.Sha, 2 O.Yamamoto, 3 M.Harada, 4 F.Marotta

Conferences

The 16th Annual Meeting of the Japanese Society for Complementary and Alternative Medicine
30 Nov~1 Dec May 2013 – Kanazawa, Japan

33

Biological evaluations of DTS and YHK on neuronal differentiation in PC12 cell model

Center for Chinese Medicine R&D - By a University located in Hong Kong

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