Research Classification
All research
Clinical Trials
Award-winning
International Medical Journal Publishes Research
1
Effect and Application of Yojyo Henshiko
S. Sha 1), N. Yanaihara 2)
Conferences

16th General Meeting of Medical and Pharmaceutical Society for Wakan-Yaku
28th~29th August 1999 – Makuhari, Japan

2
Clinical Trials
Clinical Application and Efficacy of a New Chinese Medical Herb Prescription: “Yojyo Henshiko”
S. Sha 1), N. Yanaihara 2)
Conferences

2nd Annual Meeting of the Japanese Society for Alternative Medicine & Treatment
28th~29th August 1999 – Makuhari, Japan

3
Effect of “Yojyo Henshiko, a new Chinese Herb Prescription”, on Serum ALT and AST Levels in Patients with Hepatic Diseases
S. Sha 1), M.Harada 2), N. Yanaihara 3)
Conferences

3rd International Conference on Therapies for Viral Hepatitis
12th~16th December 1999 – Maui, Hawai, U.S.A.

IASL-APASL JOINT MEETING 2000
2nd~7th June 2000 – Fukuoka, Japan

4
Beneficial Effect of a Controlled Chinese Herbal Remedy, K-17.22, in CCL4-Induced Liver Toxicity; an in Vivo and in Vitro Study
F.Marotta 1), A.Rouge 2), H.Anzulovic 2), M.Harada 3), G.M.Ideo 1), K.Kajikawa 4), N.Yanaihara 5), G.Princess 2), G.Ideo 1)
Conferences

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
7th~9th June 2001 – Shimonoseki, Japan

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

5
Ischemia-Reperfusion Liver Injury: Effect of a Nutritional Approach with K-17.22 on Eudogenous Hepatic Antioxidant System
F.Marotta 1), G.M.Ideo 1), MG Seal 2), CC Wu 3), P Safran 2), M.Harada 4), N. Yanaihara 4), G.Ideo 1)
Conferences

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
6th~9th June 2001 – Shimonoseki, Japan

6
A Nutritional Approach with Herbal Remedy K-17.22 Delays the Onset of Spontaneous Chronic Pancreatitis
F.Marotta 1), M.Harada 2), MG Seal 2), J.Bertuccelli 3), A.Rouge 3), H.Anzulovic 3), N.Yanaihara 4), G.Ideo 1)
Conferences

25th National Congress of the Italian Association of Pancreatology Study
20th~22nd June 2001 – Como, Italy

7
Effect of a Nutritional Approach with K-17.22 on Endogenous Hepatic Antioxidant System
F.Marotta, M. Harada, N. Yanaihara, G.M. Ideo, MG Seal, CC Wu, P Safran, G.Ideo
Conferences

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

8
The Effect of the Yojyo Hen Shi Ko for the liver diseases -Specially for the Hepatitis Type C
M.Harada, N.Yanaihara, F.Marotta, I.Yoshijima, H.Shimizu, K.Hosokawa, Y.Tsuji, Y.Harada, S.Sha
Conferences

The 43th The Journal of All Japan Hospital Association
20th October 2001 – Saitama, Japan

9
The Effect of the Tablets
S. Sha 1), M. Harada 2), N. Yanaihara 3)
Conferences

The 4th Annual Meeting of the Japanese Society for Alternative Medicine and Treatment
10th~11th November 2001 – Osaka, Japan

10
Clinical Trials
Effect of “Yojyo Henshiko (YHK)”, in Patients with Hepatic Diseases
S. Sha 1), M. Harada 2), N. Yanaihara 3)
Conferences

HEP DART 2001
16th~20th December 2001 – Maui, Hawai, U.S.A.

11
Effect of K-17.22, a Novel Phytoterapeutic Agent, on DNA Synthesis and Liver Enzyme Release in Experimental Liver Damage
F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), A.Helmy 4), P.Safran 2), M.Harada 5)
Conferences

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

12
Is There Any Liver Anti-Fibrotic Effect of K-17.22? An Experimental Study with Immunohistochemical Analysis in A Rat Model
F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), E. Oliva 4), P.Safran 2), M.Harada 5)
Conferences

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

13
Clinical Trials
Award-winning
YHK, A Novel Herbal Remedy with Effective Antifibrotic Action, in Chronic Liver Disease: A Pilot Clinical Study Aiming to a Successful Integrative Medicine Development
M.Harada 1), F.Marotta 2), S.Sha 3), E.Minelli 4)
Conferences

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

14
Effect of a Novel Phytoterapeutic on DNA Synthesis and Enzyme Release In Experimental Liver Damage
F.Marotta 1), YR-Shield 2), E.Minelli 3), A Helmy 4), P.Safran 2)
Conferences

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

15
For “Shining of Life Force”-Basics & Potential Contribution of Yojyo Foods
S. Sha
Conferences

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

16
An In Vitro Study on the Beneficial Effect of YHK, A Natural Herbal Compound, on Metal-Induced Oxidative Damage of Hepatocytes and Mithocondrial Fraction
F.Marotta 1), P.LeCroix 2), M.Harada 3), K.Masulair 4), C.Turnes 2), P.Safran 3), E.Fesce 1)
Conferences

7th International ISSX Meeting
29th August~2nd September 2004 – Vancouver, Canada

17
Herbal Products for Liver Disease: A Therapeutic Challenge for the New Millenium
F.Marotta
Conferences

Hiroshima University M.D. Lecture Presentation
4th October 2004 – Hiroshima, Japan

18
Award-winning
Exploring Strategies to Treat NASH: Beneficial Effect of YHK on Metal-Induced Oxidative Damage of Hepatocytes and Lysosomal Fraction
F.Marotta, P.LeCroix, M.Harada, K.Masulair, C.Turnes, L.Mondazzi, P.Safran, E.Fesce
Conferences

Third JSH Single Topic Conference
7th~8th October 2004 – Kochi, Japan

4th World Congress on Trauma, Sjock, Inflammation and Sepsis – Pathophysiology, Immune Consequences and Therapy
4th November 2004 – Munich, Germany

2nd Natural Health Product Conference
11th~13th February 2005 – Vancouver, Canada

19
Integrative Medicine in the III Millenium: Herbal Products for Liver Disease
F. Marotta, E. Minelli, U. Solimene, SH Sha.
Conferences

Saudi Gastroenterology Association
10th November~2nd December 2004 – Saudi Arabia

20
Herbal Products for Liver Disease
Conferences

Asian Pacific Association for the Study of the Liver(APASL) Conference 2004
11th December 2004~15th January 2005 – New Delhi, India

21
International Medical Journal Publishes Research
Liver Exposure to Xenobiotics: The Aging Factor and Potentials for Functional Foods
F. MAROTTA, P. LECROIX, M. HARADA, K. MASULAIR, P. SAFRAN, A. LORENZETTI, SK ONO-NITA, and P. MARANDOLA
Publication

REJUVENATION RESEARCH Volume 9, Number 2, 2006

22
Clinical Trials
International Medical Journal Publishes Research
Yo Jyo Hen Shi Ko (YHK) Improves Transaminases in Nonalcoholic Steatohepatitis(NASH): A Randomized Pilot Study
Nilesh Chande, Maggie Laidlaw, Paul Adams, Paul Marotta
Conferences

1st Annual Canadian Association for the Study of the Liver Winter Meeting: Updates in Hepatology
19th~22nd March 2005 – Canada

Publication

Digestive Diseases and Sciences 2006

23
Carcinogen-Metabolizing Enzyme Activity in the Liver: Beneficial Effect of the Phytotherapeutic Compound YHK
F. Marotta 1), P. LeCroix 2), M. Harada 3), K. Masulair 4), P. Safran 3), E. Fesce 1)
Conferences

8th World Congress on Gastrointestinal Cancer
28th June~1st July 2006 – Barcelona, Spain

24
International Medical Journal Publishes Research
Nonalcoholic Steatohepatitis (NASH) in OB/OB Mice Treated with Yo Jyo Hen Shi Ko (YHK): Effects on Peroxisome Proliferator-Activated Receptors (PPARs) and Microsomal Triglyceride Transfer Protein (MTP)
J. T. Stefano, C. P. M. S. de Oliveira, M. L. Correˆa-Giannella, V. M. R. de Lima, S. V. de Sa, E. P. de Oliveira, E. S. de Mello, D. Giannella-Neto, V. A. F. Alves, F. J. Carrilho
Publication

Digestive Diseases and Sciences Vol.52, 2007

25
International Medical Journal Publishes Research
YHK(YojyoHenshiKo), a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet
Lima V.M.1, Oliveira C.P 1), Sawada L.Y 1), Barbeiro H.V 2), Mello E.S 3), Soriano F.G 2), Alves V.A.F 3), Caldwell S.H 4), Carrilho F.J 1)
Publication

“Liver International” Volume 27, Issue2

26
International Medical Journal Publishes Research
In vitro study on the mechanisms of action of a novel phytotherapeutic compound against human hepatoma cells
F Marotta;1,3 M Harada;2 KL Goh;3 A Lorenzetti;4 P Marandola;4 E Minelli 1
Publication

Annals of Hepatology
1st April 2007

27
International Medical Journal Publishes Research
Phytotherapeutic compound YHK exerts an inhibitory effect on early stage of experimentally-induced neoplastic liver lesions
Marotta F;1,4 Harada M;2 Goh KL;3 Lorenzetti A;1 Gelosa F;1 Minelli E4
Conferences

International Symposium on: Functional Foods in Europe – International Developments in Science and Health Claims
9th~11th May 2007 – St Julian’s, Malta

American Institute for Cancer Research (AICR) Annual Conference on Food, Nutrition, Physical Activity and Cancer
6th~7th November 2008 – Washington DC, U.S.A.

Publication

Annals of Hepatology 2006

28
Inhibitory Action of a Novel Phytotherapeutic Compound Against Human Hepatoma Cells
1Minelli E., 2Harada M., 1, 3Marotta F., 3Goh KL
29
International Medical Journal Publishes Research
Anti-inflammatory And Anti-mutagenic Effect Of Yhk Phytocompound In Hepatocytes: In View Of An Age-management Liver Protecting Approach
Conferences

Strategies for Engineered Negligible Senescence (SENS), Sixth Conference
3rd~7th September 2013

Publication

Rejuvenation Research 2013

30
International Medical Journal Publishes Research
Yo Jyo Hen Shi Ko (YHK) Modulates the Expression of Proteins Involved in de novo Lipogenesis and Lipid Exportation in Experimental Nonalcoholic Steatohepatitis (NASH)
I. Pereira, C. de Oliveira, J. Stefano, V. Debas, N. Halla, J. Alves, F. Laurindo, F. Carrilho
Publication

Journal of Pharmacy and Nutrition Science 2013

31
The use of nutraceuticals in chronic liver disease: Myths, Facts and Dangers
Marotta F
Conferences

AMMG 14th Clinical Applications for Age Management Medicine
2nd~5th May 2013

32
A study of Chinese Medical herb prescription prevents Chronic and other liver disease
1 S.Sha, 2 O.Yamamoto, 3 M.Harada, 4 F.Marotta
Conferences

The 16th Annual Meeting of the Japanese Society for Complementary and Alternative Medicine
30 Nov~1 Dec May 2013 – Kanazawa, Japan

33
Biological evaluations of DTS and YHK on neuronal differentiation in PC12 cell model
Center for Chinese Medicine R&D - By a University located in Hong Kong

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